Correction of a nucleotide-excision-repair mutation by human chromosome 19 in hamster-human hybrid cells
Journal Article
·
· Somatic Cell Mol. Gen.; (United States)
A UV-sensitive mutant line of CHO cells, UV20, was shown to be phenotypically corrected to resistance by fusion with human lymphocytes or fibroblasts. Only human chromosome 19 correlated with the DNA repair phenotype of resistant hybrid clones and their resistant or sensitive subclones. This study demonstrates the mapping of a human repair gene by direct selection of complementing hybrids in the presence of a DNA-damaging agent (mitomycin C).
- Research Organization:
- Lawrence Livermore National Lab., CA
- OSTI ID:
- 5554941
- Journal Information:
- Somatic Cell Mol. Gen.; (United States), Journal Name: Somatic Cell Mol. Gen.; (United States) Vol. 11:1; ISSN SCMGD
- Country of Publication:
- United States
- Language:
- English
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Fri Sep 27 00:00:00 EDT 1985
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Correction of chromosomal instability and sensitivity to diverse mutagens by a cloned cDNA of the XRCC3 DNA repair gene
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CULTURES
CHO CELLS
CHROMOSOMES
CLONE CELLS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DNA REPAIR
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENES
GENETIC MAPPING
HYBRIDIZATION
LEUKOCYTES
LYMPHOCYTES
MAPPING
MATERIALS
MITOMYCIN
MUTATIONS
NUCLEOTIDES
ORGANIC COMPOUNDS
PHENOTYPE
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SOMATIC CELLS
ULTRAVIOLET RADIATION
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL MATERIALS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BLOOD
BLOOD CELLS
BODY FLUIDS
CELL CULTURES
CHO CELLS
CHROMOSOMES
CLONE CELLS
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DNA REPAIR
DRUGS
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENES
GENETIC MAPPING
HYBRIDIZATION
LEUKOCYTES
LYMPHOCYTES
MAPPING
MATERIALS
MITOMYCIN
MUTATIONS
NUCLEOTIDES
ORGANIC COMPOUNDS
PHENOTYPE
RADIATIONS
RADIOSENSITIVITY
RECOVERY
REPAIR
SOMATIC CELLS
ULTRAVIOLET RADIATION