Distribution of arterial blood flow in human hepatic cancer during chemotherapy--examination by short-lived /sup 81m/Kr

Journal Article · Mon Apr 01 04:00:00 EST 1985 · Surgery; (United States)

OSTI ID:5553375

Sasaki, Y; Imaoka, S; Hasegawa, Y; Nakano, S; Ishikawa, O; Ohigashi, H; Taniguchi, K; Koyama, H; Iwanaga, T; Terasawa, T

Using the characteristics of short-lived radioisotope, /sup 81m/Kr (half- life = 13 seconds), the authors studied the distribution of arterial blood flow of human hepatic cancers during intra-hepatic arterial chemotherapy. Sixteen patients with primary and metastatic cancer were catheterized into the hepatic artery during operation. /sup 81m/Kr solution was continuously infused via the hepatic artery with the patient in the supine, upright, right-side down, and left-side down positions. The frontal and right-side images of the liver were taken with a scinticamera. The tumor/nontumor ratio of the hepatic arterial flow in the supine position was more than one in 14 of 15 patients. The patterns of arterial flow distribution of /sup 81m/Kr in the four positions were compared. In 11 patients the tumor/nontumor ratio of one of the other positions was significantly higher than that of the supine position. It is expected that this quantitative measurement will be a good indicator for evaluation of a drug's accessibility to the tumor in the first pass. Moreover, the choice of the most effective position for intra-arterial infusion chemotherapy by this test will be possible to increase the relative amount of drug reaching the tumor. This technique may be applicable mainly to short-term drug infusion.

• Research Organization: Center for Adult Diseases, Osaka, Japan
• OSTI ID: 5553375
• Journal Information: Surgery; (United States), Journal Name: Surgery; (United States) Vol. 97:4; ISSN SURGA
• Country of Publication: United States
• Language: English

Related Subjects

550600 -- Medicine
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ARTERIES
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CHEMOTHERAPY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GLANDS
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LABELLED COMPOUNDS
LIVER
METASTASES
NEOPLASMS
NUCLEI
ORGANS
PATIENTS
POSITIONING
RADIOISOTOPE SCANNING
RADIOISOTOPES
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
THERAPY
TRACER TECHNIQUES
YEARS LIVING RADIOISOTOPES