Cancer risks after diagnostic doses of 131I with special reference to thyroid cancer

Journal Article · Tue Jan 01 04:00:00 EST 1991 · Cancer Detection and Prevention; (United States)

OSTI ID:5552884

Holm, L E ^[1]

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1. Department of Cancer Prevention, Karolinska Institute and Hospital, Stockholm (Sweden)

Between 1951 and 1969 a total of 35,074 patients less than 75 years of age (mean = 44 years) were examined with diagnostic doses of 131I. The mean administered activity of 131I was 52 microCi and the radiation dose to the thyroid gland was on the average of 0.5 Gy. The cohort was matched with the Swedish Cancer Register for the years 1958-1984. During this period, 3746 cancers occurred more than 5 years after the 131I examination, and the resulting standardized incidence ratio (SIR) was 1.01 (95% confidence interval (CI) = 0.98 to 1.04). SIR for thyroid cancer was 1.18 (95% CI = 0.88 to 1.56). The risks for both cancer of all sites and for thyroid cancer were highest 5 to 9 years after examination (SIR = 1.07 and 2.06, respectively) and did not differ from unity thereafter. With greater than or equal to 10 years of follow-up, risk was not statistically associated with the dose of 131I.

• OSTI ID: 5552884
• Journal Information: Cancer Detection and Prevention; (United States), Journal Name: Cancer Detection and Prevention; (United States) Vol. 15:1; ISSN 0361-090X; ISSN CDPRD
• Country of Publication: United States
• Language: English

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