Effects of CdCl/sub 2/ on the maternal-to-fetal clearance of /sup 67/Cu and placental blood flow

Journal Article · Tue May 01 04:00:00 EDT 1984 · Proc. Soc. Exp. Biol. Med.; (United States)

DOI:https://doi.org/10.3181/00379727-176-41853· OSTI ID:5551924

Chertok, R J; Kullgren, B; Burbank, D

Copper is an essential element while Cd is an extremely toxic heavy metal of questionable biological usefulness. Cadmium has been reported to interfere with the metabolism of Cu, be teratogenic, and decrease blood flow in the fetal placenta. Because of these reported biological interactions of Cd and Cu, this investigation was conducted to determine the effects of Cd on placental transport of /sup 67/Cu and placental blood flow in the guinea pig. All guinea pigs used were 60 +/- 1 days pregnant. A placental perfusion technique was used to measure the maternal-to-fetal clearance of /sup 67/Cu and /sup 3/H/sub 2/O across the placenta. The clearance of /sup 3/H/sub 2/O served as an indicator of placental blood flow on the maternal side of the circulation. The results indicated that an iv injection of 1 mg Cd/kg body weight resulted in an immediate increase in the clearance of /sup 67/Cu which declined over the next 8 min to an elevated level compared to the extrapolated best-fit curve of control values. This iv injection of CdCl/sub 2/ concomitantly reduced the maternal-to-fetal clearance of /sup 3/H/sub 2/O across the placenta. In conclusion, an acute exposure of the pregnant female to CdCl/sub 2/ results in an increased maternal-to-fetal clearance /sup 67/Cu and a reduced placental blood flow that can alter the supply of nutrients to the developing embryo or fetus, and therefore modify normal development.

• Research Organization: Oak Ridge National Lab., TN
• DOE Contract Number: AC05-76OR00033
• OSTI ID: 5551924
• Journal Information: Proc. Soc. Exp. Biol. Med.; (United States), Journal Name: Proc. Soc. Exp. Biol. Med.; (United States) Vol. 176:1; ISSN PSEBA
• Country of Publication: United States
• Language: English

Related Subjects

550201 -- Biochemistry-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BLOOD FLOW
CADMIUM
CLEARANCE
COPPER
COPPER 67
COPPER ISOTOPES
DATA
DAYS LIVING RADIOISOTOPES
ELEMENTS
EXPERIMENTAL DATA
FETUSES
GUINEA PIGS
HYDROGEN COMPOUNDS
INFORMATION
INHIBITION
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEMBRANE TRANSPORT
METABOLISM
METALS
NUCLEI
NUMERICAL DATA
ODD-EVEN NUCLEI
OXYGEN COMPOUNDS
RADIOISOTOPES
RODENTS
TERATOGENESIS
TOXICITY
TRANSITION ELEMENTS
TRITIUM COMPOUNDS
VERTEBRATES
WATER