Genetic differences in ethanol-induced hyperglycemia and conditioned taste aversion

Journal Article · Wed Jan 01 00:00:00 EST 1992 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(92)90463-Y· OSTI ID:5551622

Risinger, F O; Cunningham, C L ^[1]

---

1. Oregon Health Science Univ., Portland (United States)

Genetic differences in the hyperglycemic response to acute ethanol exposure and ethanol-induced conditioned taste aversion were examined using inbred mice. Adult male C57BL/6J and DBA/2J mice were injected with ethanol and blood glucose levels determined over 4 h. C57 mice demonstrated greater dose-dependent elevations in blood glucose compared to DBA mice. In a conditioned taste aversion procedure, water deprived mice received ethanol injections immediately after access to a NaCl flavored solution. DBA mice developed aversion to the ethanol-paired flavor at a lower dose than C57 mice. These results provide further support for a possible inverse genetic relationship between sensitivity to ethanol-induced hyperglycemia and sensitivity to conditioned taste aversion.

• OSTI ID: 5551622
• Journal Information: Life Sciences; (United States), Vol. 50:16; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ETHANOL
BIOLOGICAL EFFECTS
TASTE BUDS
SENSITIVITY
DOSE-RESPONSE RELATIONSHIPS
GENETIC VARIABILITY
GLUCOSE
HYPERGLYCEMIA
MICE
ALCOHOLS
ALDEHYDES
ANIMALS
BIOLOGICAL VARIABILITY
BODY
CARBOHYDRATES
HEXOSES
HYDROXY COMPOUNDS
MAMMALS
MONOSACCHARIDES
ORGANIC COMPOUNDS
ORGANS
RODENTS
SACCHARIDES
SENSE ORGANS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology