Murine serum glycoprotein gp70 behaves as an acute phase reactant
A single intraperitoneal injection of bacterial lipopolysaccharide (LPS) or its lipid A component induced high levels of glycoprotein, gp70, in sera of several strains of mice within 24 h. This serum gp70 response induced by LPS was independent of the activation of B cells and the presence of T cells. However, serological and immunohistochemical studies demonstrated the production of gp70 by hepatic parenchymal cells and its subsequent release into the circulating blood. The expression of gp70 in the serum was enhanced not only by LPS but also other inducers of acute phase reactants (APR) such as turpentine oil or polyriboinosinic-polyribocytidylic acid. Further, the serum gp70 response was kinetically identical to those of APR. These results strongly suggest that (a) the liver may be the major source for serum gp70, (b) serum gp70 behaves like an APR, (c) its expression may be controlled by a mechanism similar to that for other APR, and (d) this glycoprotein apparently behaves as a normal host constituent and not a product of a viral genome.
- Research Organization:
- Department of Immunopathology, Scripps Clinic, La Jolla, California
- OSTI ID:
- 5551440
- Journal Information:
- J. Exp. Med.; (United States), Vol. 155:2
- Country of Publication:
- United States
- Language:
- English
Similar Records
Isolation and comparison of murine luekemia virus-related glycoproteins from AKR and New Zealand mice
Sodium butyrate attenuates soybean oil-based lipid emulsion-induced increase in intestinal permeability of lipopolysaccharide by modulation of P-glycoprotein in Caco-2 cells
Related Subjects
GLUCOPROTEINS
CHEMICAL ACTIVATION
LIPOPOLYSACCHARIDES
BIOCHEMISTRY
INTRAPERITONEAL INJECTION
ANIMAL CELLS
BLOOD SERUM
IMMUNE REACTIONS
LIVER
LYMPHOCYTES
MICE
ANIMALS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOHYDRATES
CHEMISTRY
CONNECTIVE TISSUE CELLS
DIGESTIVE SYSTEM
GLANDS
INJECTION
INTAKE
LEUKOCYTES
LIPIDS
MAMMALS
MATERIALS
ORGANIC COMPOUNDS
ORGANS
POLYSACCHARIDES
PROTEINS
RODENTS
SACCHARIDES
SOMATIC CELLS
VERTEBRATES
550200* - Biochemistry