Stability of lidocaine hydrochloride in 5% dextrose injection in plastic bags
Journal Article
·
· Am. J. Hosp. Pharm.; (United States)
OSTI ID:5550571
The stability of lidocaine injection mixed with 5% dextrose injection and refrigerated or stored at room temperature was studied. Lidocaine injection was added to 5% dextrose injection to provide a lidocaine hydrochloride concentration of 4 mg/ml. Samples were assayed for lidocaine and its degradation product, 2,6-dimethylaniline, after 30, 60, and 120 days of storage at room temperature (30 degrees C) and refrigerated temperature (4 degrees C). The analysis was by a stability-indicating HPLC method. Degradation product 2,6-dimethylaniline was not detected at any assay time at either temperature. No statistically significant loss of lidocaine occurred at either temperature. Lidocaine hydrochloride injection is chemically stable for up to 120 days at either 30 degrees C or 4 degrees C when mixed with 5% dextrose injection in plastic infusion bags.
- Research Organization:
- Department of Pharmacy, University of Kansas Medical Center, Kansas City
- OSTI ID:
- 5550571
- Journal Information:
- Am. J. Hosp. Pharm.; (United States), Journal Name: Am. J. Hosp. Pharm.; (United States) Vol. 38:11; ISSN AJHPA
- Country of Publication:
- United States
- Language:
- English
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