Mammalian ets-1 and ets-2 genes encode highly conserved proteins

Journal Article · Tue Nov 01 04:00:00 EST 1988 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.85.21.7862· OSTI ID:5547113

Watson, D K; McWilliams, M J; Lapis, P; Lautenberger, J A; Schweinfest, C W; Papas, T S ^[1]

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1. National Cancer Institute, Frederick, MD (USA)

Cellular ets sequences homologous to v-ets of the avian leukemia virus E26 are highly conserved. In mammals the ets sequences are dispersed on two separate chromosomal loci, called ets-1 and ets-2. To determine the structure of these two genes and identify the open reading frames that code for the putative proteins, the authors have sequenced human ets-1 cDNAs and ets-2 cDNA clones obtained from both human and mouse. The human ETS1 gene is capable of encoding a protein of 441 amino acids. This protein is >95% identical to the chicken c-ets-1 gene product. Thus, the human ETS1 gene is homologous to the chicken c-ets-1 gene, the protooncogene that the E26 virus transduced. Human and mouse ets-2 cDNA clones are closely related and contain open reading frames capable of encoding proteins of 469 and 468 residues, respectively. Direct comparison of these data with previously published finding indicates that ets is a family of genes whose members share distinct domains.

• OSTI ID: 5547113
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (USA) Vol. 85:21; ISSN 0027-8424; ISSN PNASA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
AMINO ACIDS
ANIMALS
ARTHROPODS
BIOLOGICAL EVOLUTION
BIRDS
CARBOXYLIC ACIDS
CHICKENS
DIPTERA
DNA
DNA SEQUENCING
DROSOPHILA
FLIES
FOWL
FRUIT FLIES
GENES
INSECTS
INVERTEBRATES
MAMMALS
MAN
MICE
MICROORGANISMS
MOLECULAR STRUCTURE
NUCLEIC ACIDS
ONCOGENES
ORGANIC ACIDS
ORGANIC COMPOUNDS
PARASITES
PRIMATES
PROTEINS
RECOMBINANT DNA
RODENTS
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES
VIRUSES