Thyroid function after radiotherapy and laryngectomy for carcinoma of the larynx
Total levels of thyroxine (T4) and thyroid-stimulating hormone (TSH) were measured in 37 patients who had previously had carcinoma of the larynx treated by radiotherapy and total laryngectomy with thyroid lobectomy. Ten percent of the patients had clinical features of hypothyroidism and 30% had total T4 levels below the lower limit of normal. A further 40% had results in the low normal range. Forty-four percent of patients had raised TSH levels, 90% of these having low or low normal T4 levels. The histology of the thyroid gland was normal in all 37 patients. Attention should be given to preserving intact the vasculature of the contralateral thyroid lobe whenever it is necessary to remove the ipsilateral thyroid lobe during a laryngectomy. Proper postoperative assessment of thyroid gland function is desirable in all these patients to identify those at risk of hypothyroidism and to avoid unnecessary morbidity.
- Research Organization:
- Head and Neck Unit, Royal Marsden Hospital, London, England
- OSTI ID:
- 5546669
- Journal Information:
- Head Neck Surg.; (United States), Vol. 4:1
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
HYPOTHYROIDISM
RADIOINDUCTION
RADIOTHERAPY
SIDE EFFECTS
THYROID
BIOLOGICAL RADIATION EFFECTS
THYROXINE
TSH
CARCINOMAS
LARYNX
PATIENTS
SURGERY
AMINO ACIDS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
DISEASES
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HORMONES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIATION EFFECTS
RADIOLOGY
RESPIRATORY SYSTEM
THERAPY
THYROID HORMONES
560151* - Radiation Effects on Animals- Man
550603 - Medicine- External Radiation in Therapy- (1980-)