Absorption after subarachnoid and subdural administration of iohexol, /sup 51/Cr-EDTA, and /sup 125/I-albumin to rabbits

Journal Article · · AJNR, Am. J. Neuroradiol.; (United States)

OSTI ID:5546442

Holtz, E; Michelet, A A; Jacobsen, T

The absorption of the nonionic contrast medium iohexol, the clearance tracer /sup 51/Cr-ethylenediaminetetraacetic acid, and the blood-pool marker /sup 125/I-human serum albumin was studied after subarachnoid and subdural injection in rabbits. Subdural deposition of the contrast medium and /sup 51/Cr-ethylenediaminetetraacetic acid resulted in a faster absorption rate and higher achieved blood levels than a subarachnoid injection of the two substances, where a slow absorption to lower blood concentrations was observed. No significant differences in absorption rate could be shown after subdural and subarachnoid administration of iodine-labelled albumin. The excretion of iohexol was observed for 1 week after the intrathecal injection. For both the subdural and subarachnoid depositions, about 83% of the injected iohexol was found in urine within 24 hr after injection. The total recovery of iohexol after 1 week was 96% (range, 87%-101%).

• Research Organization: Research Department, Nyegaard and Company, Oslo, Norway
• OSTI ID: 5546442
• Journal Information: AJNR, Am. J. Neuroradiol.; (United States), Journal Name: AJNR, Am. J. Neuroradiol.; (United States) Vol. 4:3; ISSN AAJND
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ALBUMINS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOMEDICAL RADIOGRAPHY
BLOOD-BRAIN BARRIER
CARBOXYLIC ACIDS
CHELATING AGENTS
CHROMIUM 51
CHROMIUM ISOTOPES
CLEARANCE
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
FEMALES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
IOHEXOL
ISOTOPE APPLICATIONS
ISOTOPES
LABELLING
MALES
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PROTEINS
RABBITS
RADIOISOTOPES
RADIOLOGY
TRACER TECHNIQUES
UPTAKE
VERTEBRATES