Radiation-induced endometriosis in Macaca mulatta

Journal Article · Wed May 01 04:00:00 EDT 1991 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577812· OSTI ID:5545794

Fanton, J W; Golden, J G ^[1]

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1. USAF School of Aerospace Medicine, Brooks AFB, TX (USA)

Female rhesus monkeys received whole-body doses of ionizing radiation in the form of single-energy protons, mixed-energy protons, X rays, and electrons. Endometriosis developed in 53% of the monkeys during a 17-year period after exposure. Incidence rates for endometriosis related to radiation type were: single-energy protons, 54%; mixed-energy protons, 73%; X rays, 71%; and electrons, 57%. The incidence of endometriosis in nonirradiated control monkeys was 26%. Monkeys exposed to single-energy protons, mixed-energy protons, and X rays developed endometriosis at a significantly higher rate than control monkeys (chi 2, P less than 0.05). Severity of endometriosis was staged as massive, moderate, and minimal. The incidence of these stages were 65, 16, and 19%, respectively. Observations of clinical disease included weight loss in 43% of the monkeys, anorexia in 35%, space-occupying masses detected by abdominal palpation in 55%, abnormal ovarian/uterine anatomy on rectal examination in 89%, and radiographic evidence of abdominal masses in 38%. Pathological lesions were endometrial cyst formation in 69% of the monkeys, adhesions of the colon in 66%, urinary bladder in 50%, ovaries in 86%, and ureters in 44%, focal nodules of endometrial tissue throughout the omentum in 59%, and metastasis in 9%. Clinical management of endometriosis consisted of debulking surgery and bilateral salpingo-oophorectomy combined in some cases with total abdominal hysterectomy. Postoperative survival rates at 1 and 5 years for monkeys recovering from surgery were 48 and 36%, respectively.

• OSTI ID: 5545794
• Journal Information: Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 126:2; ISSN RAREA; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BARYONS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
ELECTRONS
ELEMENTARY PARTICLES
EXTERNAL IRRADIATION
FEMALE GENITALS
FERMIONS
HADRONS
IONIZING RADIATIONS
IRRADIATION
LEPTONS
MEDICINE
NUCLEONS
ORGANS
PATHOLOGICAL CHANGES
PROTONS
RADIATIONS
RADIOINDUCTION
RISK ASSESSMENT
SPACE FLIGHT
SURGERY
SURVIVAL CURVES
UROGENITAL SYSTEM DISEASES
UTERUS
WHOLE-BODY IRRADIATION
X RADIATION