Effects of antineoplastic drugs on Lactobacillus casei and radioisotopic assays for serum folate
Microbiologic assay, usually employing Lactobacillus casei, remains the standard assay for serum folate to date. Among its disadvantages have been falsely low results in patients receiving bacteriostatic agents such as antibiotics. This study examined whether commonly used antineoplastic drugs had similar effect. Methotrexate and 5-fluorouracil depressed microbiologic serum folate levels. No effect was found for adriamycin, bleomycin, BCNU, cyclophosphamide, cytosine arabinoside, vincristine, vinblastine, mechlorethamine, mithramycin, hydroxyurea, and hydrocortisone. None of the drugs affected radioassay except methotrexate, which produced falsely high folate results. Thus, it appears that L. casei assay for folate becomes unreliable in patients receiving 5-fluorouracil and radioisotopic assay becomes unreliable in those receiving methotrexate.
- Research Organization:
- Univ. of Southern California School of Medicine, Los Angeles
- OSTI ID:
- 5545629
- Journal Information:
- Am. J. Clin. Pathol.; (United States), Vol. 69:2
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANTINEOPLASTIC DRUGS
SIDE EFFECTS
BLEOMYCIN
BLOOD SERUM
RADIOASSAY
FLUOROURACILS
METHOTREXATE
CARBOXYLIC ACID SALTS
FOLIC ACID
LACTOBACILLUS
AMINO ACIDS
ANTIBIOTICS
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BACTERIA
CARBOXYLIC ACIDS
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
MICROORGANISMS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PTERIDINES
PYRIMIDINES
URACILS
VITAMIN B GROUP
VITAMINS
550600* - Medicine