Angiotensin-I-converting enzyme and gallium scan in noninvasive evaluation of sarcoidosis

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Ann. Intern. Med.; (United States)

DOI:https://doi.org/10.7326/0003-4819-90-3-328· OSTI ID:5545437

Nosal, A ^[1]; Schleissner, L A; Mishkin, F S; Lieberman, J

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1. Harbor General Hospital, Torrance, CA

Angiotensin-converting enzyme assays and gallium-scan results were obtained from 27 patients with biopsy-proven, clinically active sarcoidosis. Twenty-three of these patients had elevated converting enzyme levels, and 22 had positive gallium-scan results. Three of four patients with normal or borderline-elevated levels of angiotensin-converting enzyme also had positive gallium-scan results. Of 156 nonsarcoid patients (pulmonary and other diseases), 27 were found to have elevated serum converting enzyme levels, and 25 of these had negative gallium-scan results. These results indicate that the combination of an assay of angiotensin-converting enzyme and gallium scan increases diagnostic specificity from 83% to 99% without sacrificing sensitivity. It was concluded that the concurrent use of angiotensin-converting enzyme assay and gallium scan is of value in the diagnosis of sarcoidosis.

• OSTI ID: 5545437
• Journal Information: Ann. Intern. Med.; (United States), Journal Name: Ann. Intern. Med.; (United States) Vol. 90:3; ISSN AIMEA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ANGIOTENSIN
BIOASSAY
BIOMEDICAL RADIOGRAPHY
BIOPSY
BODY
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
ELEMENTS
ENZYMES
GALLIUM
GLOBULINS
LUNGS
MEDICINE
METALS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOISOTOPE SCANNING
RADIOLOGY
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SCINTISCANNING
SYMPATHOMIMETICS