Estimation of glomerular filtration rate from low-dose injection of iohexol and a single blood sample

Journal Article · Sun Mar 31 23:00:00 EST 1991 · Investigative Radiology; (USA)

DOI:https://doi.org/10.1097/00004424-199104000-00009· OSTI ID:5545139

Thomsen, H S; Hvid-Jacobsen, K ^[1]

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1. Univ. of Copenhagen, (Denmark)

Clearance of a small dose of iohexol (7 g I) was compared with the glomerular filtration rate (GFR) marker {sup 51}Cr EDTA in 11 healthy volunteers. The two tracers were injected simultaneously. The plasma concentration of iohexol was measured with x-ray fluorescence technique. Glomerular filtration rate was determined using blood samples drawn three and four hours after injection. An excellent correlation (0.92 less than r less than 0.97) between iohexol clearance and {sup 51}Cr EDTA clearance was found. Glomerular filtration rate can be reliably determined with a low dose of iohexol and a single blood sample obtained three hours after the injection in persons with normal serum creatinine. This new method is a good alternative to the methods using radiopharmaceuticals; it causes no radioactive burden to the patients, increases patient comfort, reduces costs, and requires no special license.

• OSTI ID: 5545139
• Journal Information: Investigative Radiology; (USA), Journal Name: Investigative Radiology; (USA) Vol. 26:4; ISSN INVRA; ISSN 0020-9996
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
CARBOXYLIC ACIDS
CHELATING AGENTS
CHEMICAL ANALYSIS
CHROMIUM 51
CHROMIUM ISOTOPES
CLEARANCE
CONTRAST MEDIA
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
EDTA
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
EXCRETION
INTERMEDIATE MASS NUCLEI
IOHEXOL
ISOTOPE APPLICATIONS
ISOTOPES
KIDNEYS
MATERIALS
METABOLISM
NONDESTRUCTIVE ANALYSIS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RADIOISOTOPES
RENAL CLEARANCE
TRACER TECHNIQUES
UROGENITAL SYSTEM DISEASES
X-RAY EMISSION ANALYSIS
X-RAY FLUORESCENCE ANALYSIS