Inoperable endobronchial obstructing lung carcinoma treated with combined endobronchial and external beam irradiation

Journal Article · Wed May 01 04:00:00 EDT 1991 · Southern Medical Journal; (USA)

OSTI ID:5544791

Cotter, G W; Herbert, D E; Ellingwood, K E ^[1]

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1. Univ. of South Alabama College of Medicine, Mobile (USA)

Thirty patients with symptomatic inoperable endobronchial obstructing lung cancer received combined external beam radiotherapy and temporary endobronchial iridium Ir 192 implants. External beam irradiation doses ranged from 5700 to 6600 cGy. Patients were given two to four temporary iridium Ir 192 implants for endobronchial radiotherapy. Individual implant doses ranged from 500 to 1500 cGy. Total implant doses ranged from 1125 to 3000 cGy. Total treatment doses ranged from 7080 cGy to 10,000 cGy. Seventy-seven percent of patients had a complete local endobronchial response to treatment, and 13% had a partial response. Ninety percent of patients experienced an improvement in their performance status using an Eastern Cooperative Oncology Group (ECOG) scale. Survival from the end of treatment was 39% at 1 year and 21% at 2 years, with the median survival at 10 months. The data from this study indicate that this form of treatment of inoperable endobronchial obstructing lung cancer is feasible and leads to a high percentage of local tumor response, improvement in patient performance status, and possibly improved survival.

• OSTI ID: 5544791
• Journal Information: Southern Medical Journal; (USA), Journal Name: Southern Medical Journal; (USA) Vol. 84:5; ISSN SMJOA; ISSN 0038-4348
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
IMPLANTS
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM 192
IRIDIUM ISOTOPES
ISOMERIC TRANSITION
ISOTOPES
LUNGS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ORGANS
PATIENTS
RADIATION DOSES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RESPIRATORY SYSTEM
SURVIVAL CURVES
THERAPY