A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Radiation Research; (USA)

DOI:https://doi.org/10.2307/3577363· OSTI ID:5543293

Sharplin, J; Franko, A J ^[1]

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1. Cross Cancer Institute, Edmonton, Alberta (Canada)

Strain differences in the radiation response of mouse lung during the early phase (before 28 weeks postirradiation) were investigated histologically. The nine strains tested were divided into three groups on the basis of the nature of the edema present, the occurrence of hyaline membranes, and the presence of fibrosis. Group 1 mice, three C57 strains, developed hyaline membranes, focal fibrosis, and a protein-rich edema containing fibrin. Group 3, CBA and two C3H strains, had only a protein-poor edema with little fibrin and developed no visible fibrosis. Group 2 mice had both types of edema and small quantities of focal fibrosis. The degree of lung impairment in mice dying of respiratory insufficiency was assessed by scoring lung acini as nonfunctional or open and presumably functional. Over 70% of acini were nonfunctional as a result of airflow obstruction. This was considered sufficient to account for death. Carbon perfusion immediately before sacrifice indicated that all types of lesions were at least partially perfused with blood. Pleural effusions were found in some individuals of two strains. The proportion of nonfunctional acini was similar in mice of the same strain with and without effusions, which would not be expected if the effusions contributed appreciably to respiratory distress in the early phase.

• OSTI ID: 5543293
• Journal Information: Radiation Research; (USA), Vol. 119:1; ISSN 0033-7587
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
BIOLOGICAL RADIATION EFFECTS
RESPIRATORY SYSTEM DISEASES
RADIOINDUCTION
FIBROSIS
GENETIC VARIABILITY
MICE
PNEUMONIA
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL VARIABILITY
BODY
DISEASES
MAMMALS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals