Nuclear-medicine progress report for quarter ending June 30, 1983

Technical Report · Sat Oct 01 04:00:00 EDT 1983

OSTI ID:5534055

Knapp, Jr, F F; Ambrose, K R; Butler, T A; Goodman, M M; Srivastava, P C

Studies with several recently developed /sup 123/-I-labeled fatty acids are described. Well defined planar images have been obtained in a dog study utilizing (E)-18-(/sup 123/I)iodo-17-octadecenoic acid, a new alkenoic fatty acid containing the radioiodide stabilized as a vinyl iodide. Studies are now in progress to prepare (E)-18-borono-17-octadecenoic acid as a kit for rapid iodination to prepare the /sup 123/I-labeled fatty acid which will allow investigators to radiolabel this agent on site for further preclinical studies. The first single photon tomographic images have been obtained with 15-(/sup 123/I)iodophenyl-3-(R,S)-methylpentadecanoic acid. This agent was readily obtained from a new kit involving the H/sup 123/I decomposition of the piperidinyl triazene derivative of 15-(p-aminophenyl)-3-(R,S)-methyl-pentadecanoic acid. The evaluation of this agent and several radioiodinated fatty acids in the in vitro beating rat heart cell system is described. The recent evaluation of radioiodinated phosphonium cations has now been extended to the preparation and testing of (E)-(-1-(/sup 125/I)iodo-1-penten-5-yl)triphenylarsonium iodide. Several shipments of raidolabeled agents were made to Medical Cooperative investigators, including three shipments of /sup 191/Os for further developing and clinical testing of the /sup 191/Os//sup 191m/Ir radionuclide generator. In addition, two shipments of cis-dichlorodiammine (/sup 195m/Pt)platinum(II) were made to participants in collaborative programs. Several radiolabeled fatty acids including 15-(p-(/sup 131/I)iodophenyl-3-(R,S)-methylpentadecanoic acid and 15-(p-(/sup 131/I)-iodophenyl)-6-tellurapentadecanoic acid were made for collaborative studies investigating the properties of these new agents.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: W-7405-ENG-26
• OSTI ID: 5534055
• Report Number(s): ORNL/TM-8827; ON: DE84000346
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CATIONS
CHARGED PARTICLES
COMPUTERIZED TOMOGRAPHY
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE 123
IODINE 131
IODINE ISOTOPES
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OSMIUM 191
OSMIUM ISOTOPES
PLATINUM 195
PLATINUM ISOTOPES
RADIOISOTOPE GENERATORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPHARMACEUTICALS
RATS
RESEARCH PROGRAMS
RODENTS
SCINTISCANNING
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
STABLE ISOTOPES
SYNTHESIS
TOMOGRAPHY
VERTEBRATES