Atrophic rhinitis and other nasal lesions induced by a 1-month exposure of F344 rats to 0.25 or 0.5 ppm ozone

Technical Report · Tue Nov 01 04:00:00 EST 1994

OSTI ID:55325

Hotchkiss, J A; Harkema, J R ^[1]; Wacnik, P W

---

1. Michigan State Univ., East Lansing, MI (United States)

Ozone, the principal oxidant pollutant of photochemical smog, is a common inhaled toxicant for metropolitan area residents. The effects of acute and chronic ozone exposure on inflammatory cell influx, hyperplasia, and secretory cell metaplasia within the surface epithelium lining rat nasal airways have previously been reported. On the other hand, there is a paucity of data describing the effects of ozone exposure on the subepithelial tissues (i.e., lamina propria and bone) of nasal turbinates. However, recently, a significant decrease in nasal turbinate bone area in rats chronically exposed (20 mo) to 1 ppm ozone was reported. The purpose of the present study was to examine the effects of a 1-mo ozone exposure on subepithelial tissue compartments of maxilloturbinates in the anterior nasal cavity of rats.

• Research Organization: Lovelace Biomedical and Environmental Research Inst., Albuquerque, NM (United States). Inhalation Toxicology Research Inst.
• OSTI ID: 55325
• Report Number(s): ITRI--144; ON: DE95007526
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
55 BIOLOGY AND MEDICINE
BASIC STUDIES
56 BIOLOGY AND MEDICINE
APPLIED STUDIES
AIR POLLUTION
ANIMAL TISSUES
BIOLOGICAL EFFECTS
INHALATION
OZONE
PROGRESS REPORT
RATS
RESPIRATORY TRACT CELLS
TOXIC MATERIALS