Response of the cornea to far ultraviolet light: an ultrastructural study

Journal Article · Tue May 01 00:00:00 EDT 1979 · Ann. Ophthalmol.; (United States)

OSTI ID:5529252

Koliopoulos, J X; Margaritis, L H

Quantitative changes were measured and ultrastructural alterations were detected in rabbit corneas after exposure to a far ultraviolet irradiation (UV). Low dose exposure (10/sup 5/ - 8 x 10/sup 5/ erg/cm/sup 2/) resulted one day later in a thicker epithelium and loss of the intercellular permeability barrier. In corneas exposed to higher doses (5 x 10/sup 6/ erg/cm/sup 2/), the epithelium was considerably thinner one day later, whereas 4 days later it was of normal thickness and the endothelial cells became degenerated. The highest UV dose exposure used (a total of 20 x 10/sup 6/ erg/cm/sup 2/ given in 4 equal daily doses) resulted in (1) swelling of the stroma and disorganization of the collagen fibers; (2) disappearance of the basement membrane; (3) degeneration of the endothelial cells; and (4) considerable reduction of epithelium thickness.

• Research Organization: National Ophthalmological Center, Athens, Greece
• OSTI ID: 5529252
• Journal Information: Ann. Ophthalmol.; (United States), Journal Name: Ann. Ophthalmol.; (United States) Vol. 11:5; ISSN ANOPB
• Country of Publication: United States
• Language: English

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BIOLOGICAL EFFECTS
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