Synthesis of amino derivatives of dithio acids as potential radiation-protective agents. Annual report, 15 March-31 August 1983
Dithio acids should be more-effective agents for hydrogen-atom transfer to effect repair of radiation-damaged DNA or other cellular substance than thiols since the pH for maximum rate of transfer for dithio acids (pH 4-6) is closer to cellular pH for maximum rate of H transfer from thiols (pH 10-11). The synthesis of several N-methylquinolinium-2-dithioacetic acid derivatives was accomplished, and the compounds were submitted for radiation-protective screening. These included the zwitterion of the dithio acid, the bis (methylthio) derivative, and the methyl-thio N-morpholino and methylthio N-piperidino derivatives. Two of the compounds had 6-methyl substituents. Various attempts to prepare aliphatic amino dithio acid esters were made, including the reaction of an imino thio ester with H/sub 2/S, the reaction of an aledhyde with morpholine and sulfur, and the reaction of a protected thiol ester with Lawesson's reagent. None of these procedures gave pure, identifiable products.
- Research Organization:
- Massachusetts Coll. of Pharmacy and Allied Health Sciences, Boston (USA)
- OSTI ID:
- 5529062
- Report Number(s):
- AD-A-165798/0/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400301 -- Organic Chemistry-- Chemical & Physicochemical Properties-- (-1987)
560100* -- Biomedical Sciences
Applied Studies-- Radiation Effects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETIC ACID
ALKYL RADICALS
AMINES
AMINO ACIDS
ATOMS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
CARBOXYLIC ACIDS
COPPER
DNA REPAIR
DRUGS
ELEMENTS
ESTERS
HYDROGEN
HYDROGEN COMPOUNDS
INORGANIC ACIDS
METALS
METHYL RADICALS
MONOCARBOXYLIC ACIDS
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADICALS
RADIOPROTECTIVE SUBSTANCES
RECOVERY
REPAIR
SULFUR
SULFURIC ACID
SYNTHESIS
THIOIC ACIDS
THIOLS
TRANSITION ELEMENTS