Re-irradiation of advanced tumors of the head and neck with fast neutrons
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
Twenty-eight patients who had received radical treatment with X rays to tumors of the head and neck presented with advanced recurrent tumors, 23 of them had also undergone surgery and 10 had more than one operation. Seven had also received chemotherapy. They were treated with neutrons to a tumor dose of 1560 cGy in 12 fractions over 26 days using the techniques of the Hammersmith Unit. Twenty-three of the tumors (82%) underwent complete regression that was maintained in 15 for at least 12 months. Despite the damage done by the previous radiation and surgery to the normal tissues, 15 patients had no complications following neutron therapy. In six patients, there was major necrosis, in seven others, this was minor. Eight tumors recurred. Five patients responded with partial regression of their tumors. The median survival was 20 months (range 4-69 months).
- Research Organization:
- Hammersmith Hospital, London, England
- OSTI ID:
- 5528570
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 2; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparison of clinical and laboratory data on neutron therapy for locally advanced tumors
Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial
Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head and Neck Cancer
Journal Article
·
Mon Nov 30 23:00:00 EST 1987
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
·
OSTI ID:5604721
Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head-and-Neck Cancer: Final Analysis of a Phase I/II Trial
Journal Article
·
Sat Dec 31 23:00:00 EST 2011
· International Journal of Radiation Oncology, Biology and Physics
·
OSTI ID:22055960
Boron Neutron Capture Therapy in the Treatment of Locally Recurred Head and Neck Cancer
Journal Article
·
Mon Oct 01 00:00:00 EDT 2007
· International Journal of Radiation Oncology, Biology and Physics
·
OSTI ID:21036250
Related Subjects
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BARYONS
BODY
BODY AREAS
DISEASES
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
HADRONS
HEAD
MEDICINE
NECK
NECROSIS
NEOPLASMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEONS
PATHOLOGICAL CHANGES
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
THERAPY
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BARYONS
BODY
BODY AREAS
DISEASES
ELEMENTARY PARTICLES
FAST NEUTRONS
FERMIONS
HADRONS
HEAD
MEDICINE
NECK
NECROSIS
NEOPLASMS
NEUTRONS
NUCLEAR MEDICINE
NUCLEONS
PATHOLOGICAL CHANGES
PATIENTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
SURVIVAL TIME
THERAPY