Chronic inhalation study of mice subjected to diethylhydroxylamine, nitroethane, and diethylamine hydrogen sulfite

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90083-4· OSTI ID:5528128

Heicklen, J ^[1]; Lundgard, R; Partymiller, K; Tankard, J; Billups, L

---

1. Pennsylvania State Univ., University Park

Institute of Cancer Research Swiss strain mice were subjected to the inhalation of 10.3 +/- 3.7 ppm diethylhydroxylamine, 10.1 +/- 4.1 ppm nitroethane, and the vapor of diethylamine hydrogen sulfite for over 2 years. Histopathologic evaluation of all organs indicated only a few significant findings. The incidence of all tumors, as well as subcutaneous tumors (principally fibrosarcomas), increased in exposed males with marginal statistical significance (P = 0.12 and 0.048, respectively). The incidence of all tumors in exposed females decreased with marked statistical significance (P < 0.0005).

• OSTI ID: 5528128
• Journal Information: Environ. Res.; (United States), Vol. 27:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
PHOTOCHEMICAL OXIDANTS
BIOLOGICAL EFFECTS
AMINES
CARCINOGENESIS
CHRONIC INTAKE
ETHYL RADICALS
HYDROGEN COMPOUNDS
HYDROXYL RADICALS
INHALATION
MICE
NITRO COMPOUNDS
SULFITES
ALKYL RADICALS
ANIMALS
INTAKE
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXYGEN COMPOUNDS
PATHOGENESIS
RADICALS
RODENTS
SULFUR COMPOUNDS
VERTEBRATES
560305* - Chemicals Metabolism &amp; Toxicology- Vertebrates- (-1987)