The carcinogenic effect of aromatic amines: an epidemiological study on the role of o-toluidine and 4,4'-methylene bis (2-methylaniline) in inducing bladder cancer in man

Journal Article · Thu Apr 01 00:00:00 EST 1982 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/0013-9351(82)90079-2· OSTI ID:5527995

Rubino, G F; Scansetti, G; Piolatto, G; Pira, E

Cause-specific mortality of 906 workers first employed 1922-1970 in a dyestuff factory in Northern Italy was compared to national figures: a marked excess of bladder cancer was observed (36 observed vs 1.23 expected deaths). The mean latent period was 25 years. The excess was higher among those with longer duration of exposure. Some excess of mortality from lung cancer, laryngeal cancer, and esophageal cancer was also found, but a clear explanation could not be provided regarding the causal role of aromatic amines. Mortality from bladder cancer was very much higher among those exposed in benzidine and naphthylamines manufacture as compared to those only exposed in use or intermittent contact. Excess bladder cancer was also very high among workers in fuchsin manufacture. There is evidence that o-toluidine and 4,4'-methylene bis(2-methylaniline) should be implicated in such excess mortality. Caution in handling these compounds is therefore suggested and the need for further studies to confirm such findings is stressed.

• Research Organization: Turin Univ., Torino, Italy
• OSTI ID: 5527995
• Journal Information: Environ. Res.; (United States), Vol. 27:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
BIOLOGICAL EFFECTS
CARCINOGENESIS
BLADDER
ONCOGENIC TRANSFORMATIONS
DYES
EPIDEMIOLOGY
LATENCY PERIOD
MANUFACTURING
MORTALITY
NEOPLASMS
PERSONNEL
BODY
DISEASES
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
URINARY TRACT
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)