Replication of respiratory syncytial virus in lungs of immunodeficient mice

Journal Article · Mon Aug 01 04:00:00 EDT 1983 · J. Reticuloendothel. Soc.; (United States)

OSTI ID:5527422

Wyde, P R; Sun, C S; Knight, V

Respiratory syncytial virus was frequently isolated during a 10-day test period from the lungs of 4- to 6-week-old immunodeficient nude (nu/nu) mice and from gamma-irradiated C3H mice inoculated intranasally with this virus, but not from similar aged and comparably inoculated normal littermates of these mice. Virus isolation rates and levels of virus in lungs in both groups of immunodeficient mice were similar. No extrapulmonary dissemination of virus was observed in any test group of mice.

• Research Organization: Influenza Research Center, Baylor College of Medicine, Houston, TX
• OSTI ID: 5527422
• Journal Information: J. Reticuloendothel. Soc.; (United States), Journal Name: J. Reticuloendothel. Soc.; (United States) Vol. 34:2; ISSN JRSOD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DISEASES
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
GROWTH
IONIZING RADIATIONS
LUNGS
MAMMALS
MICE
MICROORGANISMS
MUTANTS
ORGANS
PARASITES
RADIATION EFFECTS
RADIATIONS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RETICULOENDOTHELIAL SYSTEM
RODENTS
TISSUES
VERTEBRATES
VIRUSES