Ethanol stimulates formation of leukotriene C4 in rat gastric mucosa
Journal Article
·
· Prostaglandins; (United States)
Ethanol-induced gastric mucosal damage is characterized by microcirculatory changes such as stasis and plasma leakage. Sluggish blood flow and stasis have also been observed after administration of exogenous leukotriene (LT) C4. The effect of ethanol on the release of LTC4 from rat gastric mucosa was therefore investigated. It was found that intragastric instillation of ethanol increases gastric mucosal release of LTC4 in a dose- and time-dependent manner parallel to the production of gastric lesions. The lipoxygenase inhibitor nordihydroguaiaretic acid (NDGA) and the anti-ulcer drug carbenoxolone (CX) inhibited mucosal release of LTC4 and simultaneously protected against gastric damage caused by ethanol. It is concluded that increased formation of LTC4 and/or other 5-lipoxygenase-derived products of arachidonate metabolism may be involved in ethanol-induced gastric damage. Furthermore, inhibition of the 5-lipoxygenase pathway may be an important mechanism of action of gastric protective drugs.
- Research Organization:
- Ruhr-Univ., Bochum, Germany, F.R.
- OSTI ID:
- 5527077
- Journal Information:
- Prostaglandins; (United States), Journal Name: Prostaglandins; (United States) Vol. 2; ISSN PRGLB
- Country of Publication:
- United States
- Language:
- English
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Thu Dec 31 23:00:00 EST 1987
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·
OSTI ID:7081974
Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
ARACHIDONIC ACID
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL PATHWAYS
BLOOD FLOW
CARBOXYLIC ACIDS
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
ETHANOL
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
IN VITRO
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
METABOLISM
METABOLITES
MONOCARBOXYLIC ACIDS
MUCOUS MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RATS
REACTION KINETICS
RODENTS
TIME DEPENDENCE
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANIMALS
ARACHIDONIC ACID
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL PATHWAYS
BLOOD FLOW
CARBOXYLIC ACIDS
DOSE-RESPONSE RELATIONSHIPS
ENZYME INHIBITORS
ETHANOL
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
IN VITRO
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANES
METABOLISM
METABOLITES
MONOCARBOXYLIC ACIDS
MUCOUS MEMBRANES
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
RATS
REACTION KINETICS
RODENTS
TIME DEPENDENCE
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES