Endogenous murine leukemia virus-encoded proteins in radiation leukemias of BALB/c mice
Journal Article
·
· Virology; (United States)
To explore the role of endogenous retroviruses in radiation-induced leukemogenesis in the mouse, we have examined virus-encoded proteins in nine BALB/c leukemias by pulsechase labeling procedures and serological typing with monospecific and monoclonal antibodies. The major gag precursor protein, Pr65/sup gag/, was observed in all cases, but only three leukemias expressed detectable amounts of the glycosylated gag species, gP95/sup gag/, or its precursor, Pr75/sup gag/. No evidence was found for synthesis of gag-host fusion proteins. None of the leukemias released infectious xenotropic or dualtropic virus, but all nine expressed at least one env protein with xenotropic properties. In two instances a monoclonal antibody, 35/56, which is specific for the NuLV G/sub IX/ antigen, displayed a distinctive reactivity with this class of env protein, although this antibody is unreactive with replicating xenotropic viruses. An ecotropic/xenotropic recombinant env protein with the same 35/56 phenotype was observed in a leukemia induced by a strongly leukemogenic virus isolated from a BALB/c radiation leukemia.
- Research Organization:
- Memorial Sloan-Kettering Cancer Center, New York
- OSTI ID:
- 5525207
- Journal Information:
- Virology; (United States), Journal Name: Virology; (United States) Vol. 117:1; ISSN VIRLA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560131* -- Radiation Effects on Microorganisms-- Basic Studies-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
GENE RECOMBINATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
LEUKEMIA VIRUSES
LEUKEMOGENESIS
MAMMALS
MICE
MICROORGANISMS
NUCLEIC ACIDS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PATHOGENESIS
PROTEINS
RADIATION EFFECTS
RNA
RODENTS
VERTEBRATES
VIRUSES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOASSAY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CARCINOGENESIS
GENE RECOMBINATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
LEUKEMIA VIRUSES
LEUKEMOGENESIS
MAMMALS
MICE
MICROORGANISMS
NUCLEIC ACIDS
ONCOGENIC VIRUSES
ORGANIC COMPOUNDS
PARASITES
PATHOGENESIS
PROTEINS
RADIATION EFFECTS
RNA
RODENTS
VERTEBRATES
VIRUSES