Effect of chronic ozone exposure on lung benzo(a)pyrene oxidase, benzphetamine demethylase and monoamine oxidase

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Res. Commun. Chem. Pathol. Pharmacol.; (United States)

OSTI ID:5523916

Filipowicz, C; McCauley, R

Adult male Fischer 344 rats were exposed either to clean air or to a mixture of clean air and 0.5ppm ozone for up to one year. These populations were sampled after three and six months and when the exposure was completed. The activity of several oxidative enzymes in these rat lungs were compared. Although there was no significant increase in the ability of pulmonary microsomes to oxidize benzo(alpha)pyrene after three months of exposure to ozone, this activity and the oxidative demethylation of benzphetamine were increased after six months and a year of exposure. Aside from these enzymatic changes, electrophoretic analysis indicated that the microsomes from ozone exposed rats were enriched with a protein with an apparent molecular weight of 68,000. The activity of the two isoenzymic forms of monoamine oxidase, MAO A and MAO B, were also measured, and neither activity was affected by the ozone exposure.

• Research Organization: Wayne State Univ. School of Medicine, Detroit, MI
• OSTI ID: 5523916
• Journal Information: Res. Commun. Chem. Pathol. Pharmacol.; (United States), Journal Name: Res. Commun. Chem. Pathol. Pharmacol.; (United States) Vol. 3; ISSN RCOCB
• Country of Publication: United States
• Language: English

Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMALS
AROMATICS
BENZOPYRENE
BIOLOGICAL EFFECTS
BODY
CELL CONSTITUENTS
CHRONIC EXPOSURE
CONDENSED AROMATICS
ENZYME ACTIVITY
ENZYME INDUCTION
ENZYMES
GENE REGULATION
HYDROCARBONS
LUNGS
MAMMALS
MICROSOMES
MITOCHONDRIA
MOLECULAR WEIGHT
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
OXIDOREDUCTASES
OZONE
POLLUTION
RATS
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES