Inhibition and recovery of the replication of depurinated parvovirus DNA in mouse fibroblasts
Journal Article
·
· Adv. Exp. Med. Biol.; (United States)
Apurinic sites were introduced in the single-stranded DNA of parvovirus minute-virus-of-mice (MVM) and their effect on viral DNA synthesis was measured in mouse fibroblasts. Approximately one apurinic site per viral genome, is sufficient to block its replication in untreated cells. The exposure of host cells to a sublethal dose of UV-light 15 hours prior to virus infection, enhances their ability to support the replication of depurinated MVM. Cell preirradiation induces the apparent overcome of 10-15% of viral DNA replication blocks. These results indicate that apurinic sites prevent mammalian cells from replicating single-stranded DNA unless a recovery process is activated by cell UV-irradiation.
- Research Organization:
- Universite Libre de Bruxelles, Rhode St. Genese, Belgium
- OSTI ID:
- 5520376
- Journal Information:
- Adv. Exp. Med. Biol.; (United States), Journal Name: Adv. Exp. Med. Biol.; (United States) Vol. 179; ISSN AEMBA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DNA REPLICATION
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PURINES
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SOMATIC CELLS
SUBLETHAL IRRADIATION
ULTRAVIOLET RADIATION
VERTEBRATES
VIRUSES
560301 -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE CELLS
DNA REPLICATION
ELECTROMAGNETIC RADIATION
FIBROBLASTS
GENETIC EFFECTS
HETEROCYCLIC COMPOUNDS
IRRADIATION
MAMMALS
MICE
MICROORGANISMS
NUCLEIC ACID REPLICATION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PARASITES
PURINES
RADIATION EFFECTS
RADIATIONS
RECOVERY
RODENTS
SOMATIC CELLS
SUBLETHAL IRRADIATION
ULTRAVIOLET RADIATION
VERTEBRATES
VIRUSES