Immunoscintigraphy of recurrences of gynecologic carcinomas

Journal Article · Tue Dec 01 04:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:5519823

Chatal, J F; Fumoleau, P; Saccavini, J C; Thedrez, P; Curtet, C; Bianco-Arco, A; Chetanneau, A; Peltier, P; Kremer, M; Guillard, Y

In a first, retrospective study, 15 patients with known ovarian carcinoma were injected with /sup 131/I-OC 125 F(ab')2 monoclonal antibody (MAb). The sensitivity of immunoscintigraphy based on the number of the tumor sites was 67% (12/18). In a second, prospective study, 29 patients with gynecologic carcinoma were injected with /sup 131/I-OC 125 F(ab')2 (24) or /sup 131/I-19-9 F(ab')2 (5) MAbs according to the histologic type. Based on the number of tested anatomic sites, sensitivity was 72% and specificity 86%. In two patients injected with both /sup 131/I-OC-125 F(ab')2 and /sup 125/I-NS F(ab')2 (nonspecific immunoglobulin) 1 and 4 days before tumor resection, tumor uptake of the specific antibody was 2.2 and 4.5 times greater than that of NS. Immunoscintigraphic results were complementary with those of ultrasonography and computed tomography. Finally, in one patient injected successively with /sup 131/I-OC 125 F(ab')2 and /sup 111/In-DTPA-OC 125 F(ab')2, the recurrent tumor was visualized with both radionuclides, with /sup 111/In providing better abdominal tumor contrast but causing much greater liver radioactivity than /sup 131/I.

• Research Organization: UER de Medecine, Nantes, France
• OSTI ID: 5519823
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 28:12; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINO ACIDS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARCINOMAS
CHELATING AGENTS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
DTPA
ELECTRON CAPTURE RADIOISOTOPES
FEMALE GENITALS
GONADS
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE 131
IODINE ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MINUTES LIVING RADIOISOTOPES
MONOCLONAL ANTIBODIES
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
OVARIES
PATIENTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SCINTISCANNING
SENSITIVITY ANALYSIS
SPECIFICITY
USES