Effect of /sup 125/I interstitial radiotherapy on blood-brain barrier function in normal canine brain

Journal Article · Tue Dec 01 04:00:00 EST 1987 · J. Neurosurg.; (United States)

DOI:https://doi.org/10.3171/jns.1987.67.6.0895· OSTI ID:5518411

Groothuis, D R; Wright, D C; Ostertag, C B

Blood-brain barrier (BBB) function was studied in 14 normal dogs at time periods from 7 to 717 days after permanent insertion of 5- to 7-mCi seeds of iodine-125 (/sup 125/I) for interstitial radiation. The BBB function was measured with carbon-14-labeled alpha aminoisobutyric acid (AIB) and quantitative autoradiography, and expressed as a unidirectional blood-to-brain transfer constant, K. The /sup 125/I radiation lesions consisted of three concentric histologically and functionally distinct zones: 1) a central zone of calcified necrosis; 2) a spongy fluid-filled zone; and 3) a narrow rim (2.6 +/- 0.6 mm wide) of viable brain tissue with increased permeability. Within this rim, the mean value of the K of AIB was 5.8 times that of normal cortex. Over the 7- to 392-day time period the value of K remained rather constant, and by 716 days K values had returned to normal. There was moderate regional variation in the value of K; it was highest in the white matter and lowest in the gray matter surrounding the radiation lesion. The radiation lesion progressively increased in size from 7 to 80 days, after which there was little change. This study illustrates that the geographically circumscribed radiation from /sup 125/I seeds is accompanied by similarly well-defined changes in BBB function, which may persist for over 1 year following insertion of the /sup 125/I seed. This altered BBB function is probably responsible for the cerebral edema associated with /sup 125/I interstitial radiotherapy.

• Research Organization: Northwestern Univ., Evanston, IL
• OSTI ID: 5518411
• Journal Information: J. Neurosurg.; (United States), Journal Name: J. Neurosurg.; (United States) Vol. 67:6; ISSN JONSA
• Country of Publication: United States
• Language: English

Related Subjects

550604* -- Medicine-- Unsealed Radionuclides in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
AUTORADIOGRAPHY
BETA DECAY RADIOISOTOPES
BLOOD-BRAIN BARRIER
BODY
BRAIN
BUTYRIC ACID
CARBON 14 COMPOUNDS
CARBOXYLIC ACIDS
CENTRAL NERVOUS SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
DOGS
DYNAMIC FUNCTION STUDIES
ELECTRON CAPTURE RADIOISOTOPES
IMPLANTS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEDICINE
MONOCARBOXYLIC ACIDS
NECROSIS
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
THERAPY
VERTEBRATES