Measurement of unscheduled DNA synthesis in germ cells of the male mouse (Mus musculus)

Conference · Tue Jan 01 00:00:00 EST 1985

OSTI ID:5516999

Sega, G A

An in vivo test was used to measure induced unscheduled DNA synthesis (UDS) in the germ cells of male mice exposed to the chemicals. Early spermatids, a DNA-repair competent stage, were used to test the effects of 2-acetylaminofluorene (2-AAF), 4-acetylaminofluorene, (4-AAF), benzopyrene (BP), pyrene (PYR), and methyl methanesulfonate. Neither the two ''carcinogens'', 2AAF and BP, nor the two ''non-carcinogens'', 4AAF and PYR, induced a measurable response in the early spermatids at any exposure used. 15 refs., 7 figs., 7 tabs.

• Research Organization: Oak Ridge National Lab., TN (USA)
• DOE Contract Number: AC05-84OR21400
• OSTI ID: 5516999
• Report Number(s): CONF-8505178-1; ON: DE85014315
• Resource Relation: Conference: Collaborative study on short-term tests for genotoxicity and carcinogenicity, Cap d'Adge, France, 14 May 1985; Other Information: Portions of this document are illegible in microfiche products
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BENZOPYRENE
BIOLOGICAL EFFECTS
METHYL METHANESULFONATE
POLYCYCLIC AROMATIC AMINES
PYRENE
DNA REPLICATION
EXPERIMENTAL DATA
INTRAPERITONEAL INJECTION
MICE
ORAL ADMINISTRATION
SPERMATOGONIA
TRACER TECHNIQUES
TRITIUM COMPOUNDS
AMINES
ANIMALS
AROMATICS
CONDENSED AROMATICS
DATA
ESTERS
GAMETES
GERM CELLS
HYDROCARBONS
INFORMATION
INJECTION
INTAKE
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MUTAGENS
NUCLEIC ACID REPLICATION
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RODENTS
SULFONIC ACID ESTERS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)