Coronary blood flow and thallium 201 uptake in rejecting rat heart transplantations

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Journal of Heart Transplantation; (USA)

OSTI ID:5516210

Bergsland, J; Hwang, K; Driscoll, R; Carr, E A; Wright, J R; Curran-Everett, D C; Carroll, M; Krasney, E; Krasney, J A ^[1]

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1. Veterans Administration Medical Center, Buffalo, NY (USA)

The effects of rejection on coronary flow (CAF) in heart allografts are unclear, although previous evidence with cardiac imaging agents indicates impaired flow during advanced rejection. The purpose of this study was to measure CAF in heterotopically placed heart grafts. Lewis rats (LEW) received grafts from either syngeneic Lewis rats (LEW/LEW group) or allogeneic ACI rats (ACI/LEW group). CAF was measured in both the transplanted and native hearts with radiolabeled microspheres. Rejection was measured histologically (grades 0 (absent) to 4+ (severe)). In addition systemic blood pressure and cardiac outputs of the native hearts were determined with microspheres. Different animals were studied during relatively early (4 days) and late (6 days) rejection. Among the 4-day animals a cyclosporine-treated group was included (ACI/LEW CyA). In 6-day rats CAF in allografts was lower (0.56 +/- .06 ml/gm/min) compared with syngeneic grafts (1.72 +/- 0.4 ml/gm/min) (p less than 0.05). The CAF in the native hearts did not differ significantly but was higher than in the grafts in both groups. Heart rates were reduced in allografts (p less than 0.05). It is interesting that arterial pressure and cardiac output were significantly lower in animals bearing allogeneic than syngeneic grafts. In rats studied at 4 days graft CAF was lower than in the native heart in both the LEW/LEW and ACI/LEW groups, but there was no significant difference in behavior between groups. The same was true for a cyclosporine-treated group. Graft heart rates were similar in all 4-day rats.

• OSTI ID: 5516210
• Journal Information: Journal of Heart Transplantation; (USA), Journal Name: Journal of Heart Transplantation; (USA) Vol. 8:2; ISSN 0887-2570; ISSN JHTRE
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
CORONARIES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GRAFT-HOST REACTION
HEART
HEAVY NUCLEI
IMMUNOSUPPRESSION
IMMUNOSUPPRESSIVE DRUGS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MICROSPHERES
MUSCLES
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
TRANSPLANTS
UPTAKE
VERTEBRATES