Coronary blood flow and thallium 201 uptake in rejecting rat heart transplantations

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Journal of Heart Transplantation; (USA)

OSTI ID:5516210

Bergsland, J; Hwang, K; Driscoll, R; Carr, E A; Wright, J R; Curran-Everett, D C; Carroll, M; Krasney, E; Krasney, J A ^[1]

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1. Veterans Administration Medical Center, Buffalo, NY (USA)

The effects of rejection on coronary flow (CAF) in heart allografts are unclear, although previous evidence with cardiac imaging agents indicates impaired flow during advanced rejection. The purpose of this study was to measure CAF in heterotopically placed heart grafts. Lewis rats (LEW) received grafts from either syngeneic Lewis rats (LEW/LEW group) or allogeneic ACI rats (ACI/LEW group). CAF was measured in both the transplanted and native hearts with radiolabeled microspheres. Rejection was measured histologically (grades 0 (absent) to 4+ (severe)). In addition systemic blood pressure and cardiac outputs of the native hearts were determined with microspheres. Different animals were studied during relatively early (4 days) and late (6 days) rejection. Among the 4-day animals a cyclosporine-treated group was included (ACI/LEW CyA). In 6-day rats CAF in allografts was lower (0.56 +/- .06 ml/gm/min) compared with syngeneic grafts (1.72 +/- 0.4 ml/gm/min) (p less than 0.05). The CAF in the native hearts did not differ significantly but was higher than in the grafts in both groups. Heart rates were reduced in allografts (p less than 0.05). It is interesting that arterial pressure and cardiac output were significantly lower in animals bearing allogeneic than syngeneic grafts. In rats studied at 4 days graft CAF was lower than in the native heart in both the LEW/LEW and ACI/LEW groups, but there was no significant difference in behavior between groups. The same was true for a cyclosporine-treated group. Graft heart rates were similar in all 4-day rats.

• OSTI ID: 5516210
• Journal Information: Journal of Heart Transplantation; (USA), Vol. 8:2; ISSN 0887-2570
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
CORONARIES
BLOOD FLOW
GRAFT-HOST REACTION
DIAGNOSIS
HEART
TRANSPLANTS
THALLIUM 201
UPTAKE
BLOOD PRESSURE
IMMUNOSUPPRESSION
IMMUNOSUPPRESSIVE DRUGS
MICROSPHERES
MYOCARDIUM
RATS
ANIMALS
ARTERIES
BETA DECAY RADIOISOTOPES
BLOOD VESSELS
BODY
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEAVY NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
THALLIUM ISOTOPES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics