Use of serial bone scans in assessing response of bone metastases to systemic treatment
Journal Article
·
· Cancer (Philadelphia); (United States)
DOI:https://doi.org/10.1002/1097-0142(19810215)47:4<680::AID-CNCR2820470410>3.0.CO;2-W·
OSTI ID:5515647
The accuracy levels of serial radioisotope bone scans and conventional bone radiographs in assessing the response of bone metastases to systemic therapy were compared in 34 women with metastatic breast cancer. Each patient had measurable or evaluable nonosseous metastases, which were assessed independently of skeletal disease. The bone scan was found to be more accurate and sensitive indicator of the status of bone metastases than the radiograph. The bone scan correlated well with response of soft tissue or visceral disease, while the results of repeated bone radiographs were frequently misleading. With use of a digital model, it was possible to accurately measure the area of skeletal involvement of the bone scan, and from this derive quantitative criteria for response in bone metastases analogous to response criteria currently in use for soft tissue and visceral disease. It is suggested that serial quantitative bone scans be done, in preference to radiographs, to assess the response of bone metastases to systemic therapy.
- OSTI ID:
- 5515647
- Journal Information:
- Cancer (Philadelphia); (United States), Journal Name: Cancer (Philadelphia); (United States) Vol. 47:4; ISSN CANCA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
GLANDS
ISOTOPES
MAMMARY GLANDS
MEASURING METHODS
MEDICINE
METASTASES
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SCINTISCANNING
SKELETON
SURFACE AREA
SURFACE PROPERTIES
THERAPY
550603 -- Medicine-- External Radiation in Therapy-- (1980-)
551001 -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ACCURACY
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
COMPARATIVE EVALUATIONS
COUNTING TECHNIQUES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
GLANDS
ISOTOPES
MAMMARY GLANDS
MEASURING METHODS
MEDICINE
METASTASES
NUCLEAR MEDICINE
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
SCINTISCANNING
SKELETON
SURFACE AREA
SURFACE PROPERTIES
THERAPY