Radiosensitization of hematopoietic precursor cells (CFU/sub c/) in glioblastoma patients receiving intermittent intravenous infusions of bromodeoxyuridine (BUdR)
The potential use of bromodeoxyuridine (BUdR) as a radiosensitizer given by an intermittent intravenous route is being studied in a Phase I/II trial at the Naitonal Cancer Institute. In order to assess the extent of radiosensitization, we have studied the radiation response of human bone marrow cells CFUc taken form 6 patients prior to and after a 14-day infusion of BUdR. Varying concentrations (1000-1500 mg) of BUdR were infused for 12 hours 12 hours every 24 hours for up to 14 consecutive days. Cells survival was determined by colony formation of CFUc in soft agar suspensions. X ray survival curves were generated over a dose range of 0-300 rad and the slopes of the survival curves (D/sub 0/) before and after BUdR infusion were compared. Radiation enhancement ratios (ER)(D/sub 0/ per-BUdR/D/sub 0/ post-BUdR) ranged form 1.0-2.2 and appeared to be BUdR dose dependent. Above 650 mg/m/sub 2//12 hours is well tolerated and may result in radiosensitizaiton of CFUc in man.
- Research Organization:
- National Cancer Inst., Bethesda, MD
- OSTI ID:
- 5514546
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:4
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BUDR
RADIOSENSITIVITY EFFECTS
CELL KILLING
RADIOINDUCTION
CFU
COLONY FORMATION
GLIOMAS
PATIENTS
SKIN
SURVIVAL CURVES
X RADIATION
ANTIMETABOLITES
AZINES
BODY
BROMOURACILS
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IONIZING RADIATIONS
NEOPLASMS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC BROMINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIMIDINES
RADIATIONS
RIBOSIDES
URACILS
560151* - Radiation Effects on Animals- Man
550300 - Cytology