Measure of blood flow by the multiple radioactive microsphere technique in radiated gastrointestinal tissue

Journal Article · Mon Aug 01 04:00:00 EDT 1983 · Am. J. Clin. Oncol.; (United States)

DOI:https://doi.org/10.1097/00000421-198308000-00012· OSTI ID:5514375

Delgado, G; Butterfield, A B; Dritschilo, A; Hummel, S; Harbert, J; Petrilli, E S; Kot, P A

In this study, two different radioactive microspheres were used to measure blood flow of an irradiated segment of small intestine in four dogs before, and 12 days after, irradiation with 2000 rad. The technique and implications are discussed. Using multiple radioactive microspheres, the study demonstrated an increased blood flow in irradiated tissues twelve days after a single dose of 2000 rad. There was also an increase in blood flow to adjoining nonradiated segments of intestine in the same animal. These observations may be of significance in clinical applications of radiation therapy and surgery. A major surgical concern is the impaired healing of irradiated tissue in the immediate postradiation period. The mechanism of this has generally implicated decreases in the perfusion of irradiated tissue. No decrease in blood flow was shown in this study, suggesting that other mechanisms, e.g., stem cell depletion, should be considered. Further studies of this type are recommended to increase understanding of the blood flow in irradiated tissue.

• Research Organization: Georgetown University Hospital, Washington, DC
• OSTI ID: 5514375
• Journal Information: Am. J. Clin. Oncol.; (United States), Journal Name: Am. J. Clin. Oncol.; (United States) Vol. 6:4; ISSN AJCOD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD FLOW
BODY
CARDIOVASCULAR SYSTEM
CERIUM
DIGESTIVE SYSTEM
DOGS
DRUGS
DYNAMIC FUNCTION STUDIES
ELEMENTS
GASTROINTESTINAL TRACT
HEART
LABELLED COMPOUNDS
MAMMALS
METALS
MICROSPHERES
ORGANS
RADIATION EFFECTS
RADIOPHARMACEUTICALS
RARE EARTHS
SOMATIC CELLS
STEM CELLS
STRONTIUM
VERTEBRATES