Information profiles on potential occupational hazards: Phthalates. Draft report (Second)

Technical Report · Mon Mar 01 04:00:00 EST 1982

OSTI ID:5512102

Information profiles are presented for these phthalates: butyl benzyl phthalate, diallyl phthalate, di-n-butyl phthalate, di-2-ethylhexyl phthalate, diethyl phthalate, diisodecyl phthalate, diisononyl phthalate, dimethyl phthalate, ditridecyl phthalate, diundecyl phthalate, N-dexy-N-decyl phthalate and mixed dialkyl (C7 to C11) phthalates. In general, the phthalates had a low order of acute toxicity. Histological damage to the lungs, liver, and kidneys was associated with acute oral and/or intraperitoneal exposures to some of the compounds. Others have caused slight skin and eye irritation. Repeated oral exposure to many of the esters resulted in liver and/or kidney damage. Ingestion of di-n-butyl phthalate in humans caused nausea, dizziness, photophobia, lacrimation and conjunctivitis. Patients receiving blood stored in polyvinvyl chloride bags that contained residual di-2-ethylhexyl phthalate suffered a respiratory distress syndrome called shock lung. Neurological effects have been reported in workers exposed to a mixture of phthalate esters in production vapors. Epidemiological studies of di-2-ethylhexyl phthalate showed no adverse health effects.

• Research Organization: Syracuse Research Corp., NY (USA). Center for Chemical Hazard Assessment
• OSTI ID: 5512102
• Report Number(s): PB-89-215818/XAB; SRC-TR--82-520
• Country of Publication: United States
• Language: English

Related Subjects

552000 -- Public Health
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
BIOLOGICAL EFFECTS
CARBOXYLIC ACID SALTS
CHEMICAL ANALYSIS
CONTROL EQUIPMENT
EQUIPMENT
INDUSTRIAL MEDICINE
MATERIALS
MEDICINE
OCCUPATIONAL EXPOSURE
OCCUPATIONAL SAFETY
PHTHALATES
PRODUCTION
SAFETY
TOXIC MATERIALS
TOXICITY