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Threshold concentration of ozone causing an increase in bronchial reactivity in humans and adaptation with repeated exposures

Journal Article · · Am. Rev. Respir. Dis.; (United States)
OSTI ID:5509781
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To determine the lowest concentration of ozone that causes an increase in bronchial reactivity to histamine and to determine whether adaptation to this effect of ozone develops with repeated exposures, we studied 19 healthy adult subjects. Bronchial reactivity was assessed by measuring the rise in specific airway resistance (delta SRaw) produced by inhalation of 10 breaths of histamine aerosol (1.6% solution). Results indicate that the threshold concentration of ozone causing an increase in bronchial reactivity in healthy human subjects is between 0.2 and 0.4 ppm, and that adaptation to this effect of ozone develops with repeated exposures. The threshold concentration of ozone identified in other studies as causing changes in symptoms, lung volumes, or airway resistance was also between 0.2 and 0.4 ppm, and the time course of the development of tolerance to ozone in these other studies was similar to hat observed in our study. We propose that the appearance of symptoms, changes in pulmonary function, and the increase in bronchial reactivity may be caused by a change in the activity of afferent nerve endings in the airway epithelium.

OSTI ID:
5509781
Journal Information:
Am. Rev. Respir. Dis.; (United States), Journal Name: Am. Rev. Respir. Dis.; (United States) Vol. 124:3; ISSN ARRDA
Country of Publication:
United States
Language:
English

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Related Subjects

551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AMINES
ANIMAL TISSUES
ANIMALS
AZOLES
BODY
BRONCHI
COLLOIDS
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
DYNAMIC FUNCTION STUDIES
EPITHELIUM
HETEROCYCLIC COMPOUNDS
HISTAMINE
IMIDAZOLES
INHALATION
INTAKE
MAMMALS
MAN
NERVES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OZONE
PRIMATES
RESPIRATORY SYSTEM
SENSITIVITY
SOLS
TISSUES
TOLERANCE
TOXICITY
VERTEBRATES