The selenium-75-homocholic acid taurine test reevaluated: combined measurement of fecal selenium-75 activity and 3 alpha-hydroxy bile acids in 211 patients

Journal Article · Sat Jun 01 04:00:00 EDT 1991 · Journal of Nuclear Medicine; (United States)

OSTI ID:5508733

van Tilburg, A J; de Rooij, F W; van den Berg, J W; Kooij, P P; van Blankenstein, M ^[1]

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1. Department of Internal Medicine II, University Hospital Dijkzigt, Rotterdam (Netherlands)

The recommended reference values for the selenium-75-homocholic acid taurine (75SeHCAT) test, used in the analysis of chronic diarrhea, were evaluated in 211 patients by comparing simultaneous measurements of 3 alpha-hydroxy bile acids and 75Se activity in daily collected stools. An initial evaluation in 11 patients showed that the fecal collection method, which allows inspection and additional analysis of stools, was equivalent to the abdominal retention method. Selenium-75-HCAT whole-body retention half-life (WBR50) was greater than 2.8 days in less than 10% of the patients with bile acid malabsorption and less than 1.7 days in less than 10% of the normals. We recommend that a 75SeHCAT WBR50 less than 1.7 days is abnormal, a WBR50 greater than 2.8 days is normal, and a WBR50 in the range 1.7-2.8 days is equivocal, which was the case in 48% (94/195) of the patients in this study.

• OSTI ID: 5508733
• Journal Information: Journal of Nuclear Medicine; (United States), Journal Name: Journal of Nuclear Medicine; (United States) Vol. 32:6; ISSN 0161-5505; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
BETA DECAY RADIOISOTOPES
BILE ACIDS
BIOLOGICAL HALF-LIFE
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIARRHEA
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVALUATION
EVEN-ODD NUCLEI
FECES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOTOPES
LABELLED COMPOUNDS
MATERIALS
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PATIENTS
RADIOISOTOPES
RADIOPHARMACEUTICALS
SELENIUM 75
SELENIUM ISOTOPES
STEROIDS
STEROLS
SULFONIC ACIDS
SYMPTOMS
TAURINE
WASTES