Poor survival of treatment-related acute nonlymphocytic leukemia

Journal Article · Wed Aug 29 00:00:00 EDT 1990 · JAMA, Journal of the American Medical Association; (United States)

DOI:https://doi.org/10.1001/jama.1990.03450080092038· OSTI ID:5506229

Neugut, A.I. Nieves, J.; Murray, T; Tsai, Weiyann ^[1]; Robinson, E ^[2]

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1. Columbia Univ., New York (USA)
2. Northern Israel Oncology Center, Haifa (Israel)

Population-based data on more than 1 million patients registered in the Surveillance, Epidemiology, and End-Results Program of the National Cancer Institute, 1973-1984, were analyzed to determine the survival of patients with de novo acute nonlymphocytic leukemia (ANLL) and following a first primary tumor treated (with chemotherapy and/or radiation therapy) or untreated. Cases that occurred within 12 months of the first malignant neoplasm were excluded. Survival was estimated using Cox proportional-hazards modeling, with age, sex, and specific type of ANLL as covariates. The 6,271 patients with de novo ANLL had an estimated 12-month survival of 30%, while the 107 patients with treatment-related ANLL had an estimated 12-month survival of 10%. The authors conclude that ANLL that occurs after chemotherapy or radiation therapy is biologically more aggressive and/or resistant to therapy than spontaneous ANLL. This provides a rationale for current studies on treatment-induced cellular changes and on more aggressive therapy for these patients.

• OSTI ID: 5506229
• Journal Information: JAMA, Journal of the American Medical Association; (United States), Journal Name: JAMA, Journal of the American Medical Association; (United States) Vol. 264:8; ISSN 0098-7484; ISSN JAMAA
• Country of Publication: United States
• Language: English

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