Detection of antibodies to single-stranded DNA in naturally acquired and experimentally induced viral hepatitis
Journal Article
·
· J. Med. Virol.; (United States)
A sensitive ''Farr'' assay, utilizing /sup 125/I-labelled DNA was developed for detecting antibody to single-stranded DNA (anti-ssDNA). The test was shown to be specific and as sensitive as assays using /sup 14/C-labelled DNA, for the detection of antibody in patients with connective tissue diseases. Groups of sera from patients with naturally acquired viral hepatitis and experimentally infected chimpanzees were tested for anti-ssDNA by the /sup 125/I assay and by counterimmunoelectrophoresis (CIEP). No consistent pattern was observed with either technique, indicating the elevated levels of this antibody are not as reliable markers of parenchymal liver damage as had been previously suggested.
- OSTI ID:
- 5504130
- Journal Information:
- J. Med. Virol.; (United States), Vol. 6:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
ANTIGEN-ANTIBODY REACTIONS
DIAGNOSIS
IODINE 125
DIAGNOSTIC USES
CARBON 14 COMPOUNDS
DNA
INFECTIOUS HEPATITIS
LABELLED COMPOUNDS
LIVER
PATIENTS
SPECIFICITY
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
USES
VIRAL DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550701 - Microbiology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANTIGEN-ANTIBODY REACTIONS
DIAGNOSIS
IODINE 125
DIAGNOSTIC USES
CARBON 14 COMPOUNDS
DNA
INFECTIOUS HEPATITIS
LABELLED COMPOUNDS
LIVER
PATIENTS
SPECIFICITY
BETA DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NUCLEI
NUCLEIC ACIDS
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
USES
VIRAL DISEASES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550701 - Microbiology- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques