Thallium-201 kinetics in nonischemic canine myocardium

Journal Article · Fri Jan 01 04:00:00 EST 1982 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.65.1.70· OSTI ID:5503921

Okada, R D ^[1]; Jacobs, M L; Daggett, W M

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1. Massachusetts General Hospital, Boston

Myocardial thallium-201 (/sup 201/Tl) kinetics have not been precisely defined because reliable techniques to determine continuous activity in vivo have not been available. In this study, an implantable miniature cadmium telluride radiation detection device was inserted through the left ventricular apex, positioned against the endocardium, and used for continuous on-line monitoring of myocardial /sup 201/Tl activity for 260-810 minutes in 18 dogs. Blood was serially sampled and counted. Microsphere-determined myocardial blood flow was measured before administration of /sup 201/Tl and was not significantly different from that measured at the end of the experiment in 11 of 18 dogs. Thallium was administered intravenously. Myocardial and blood activity curves were analyzed using a nonlinear least-squares estimation of the decay constant lambda (min/sup -1/). The mean final blood lambda/sub 3/ was almost identical to the mean myocardial lambda. The data suggest that /sup 201/Tl washout after peak activity is reached in nonischemic myocardium is mono-exponential. The rate of /sup 201/Tl clearance from the myocardium is related to the rate of /sup 201/Tl clearance from the blood after i.v. administration of the tracer.

• OSTI ID: 5503921
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 65:1; ISSN CIRCA
• Country of Publication: United States
• Language: English

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560162 -- Radionuclide Effects
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& Toxicology-- Animals
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
CDTE SEMICONDUCTOR DETECTORS
CLEARANCE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HEAVY NUCLEI
IMAGES
INJECTION
INTAKE
INTRAVENOUS INJECTION
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEASURING INSTRUMENTS
MUSCLES
MYOCARDIAL INFARCTION
MYOCARDIUM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIATION DETECTORS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SEMICONDUCTOR DETECTORS
THALLIUM 201
THALLIUM ISOTOPES
TRACER TECHNIQUES
VERTEBRATES