Late effects on gonadal function of cyclophosphamide, total-body irradiation, and marrow transplantation
One hundred thirty-seven patients had gonadal function evaluated 1-11 years after marrow transplantation. All 15 women less than age 26 and three of nine older than age 26 who were treated with 200 mg/kg cyclophosphamide recovered normal gonadotropin levels and menstruation. Five have had five pregnancies resulting in three live births, one spontaneous abortion, and one elective abortion. Three of 38 women who were prepared with 120 mg/kg cyclophosphamide and 920-1200 rad total-body irradiation had normal gonadotropin levels and menstruation. Two had pregnancies resulting in one spontaneous and one elective abortion. Of 31 men prepared with 200 mg/kg cyclophosphamide, 30 had normal luteinizing hormone levels, 20 had normal follicle-stimulating hormone levels, and 10 of 15 had spermatogenesis. Four have fathered five normal children. Thirty-six of 41 men prepared with 120 mg/kg cyclophosphamide and 920-1750 rad total-body irradiation had normal luteinizing hormone levels, ten had normal follicle-stimulating hormone levels, and 2 of 32 studied had spermatogenesis. One has fathered two normal children. It was concluded that cyclophosphamide does not prevent return of normal gonadal function in younger women and in most men. Total-body irradiation prevents return of normal gonadal function in the majority of patients.
- Research Organization:
- Fred Hutchinson Cancer Research Center, Seattle, Washington
- OSTI ID:
- 5502430
- Journal Information:
- Transplantation; (United States), Journal Name: Transplantation; (United States) Vol. 36:3; ISSN TRPLA
- Country of Publication:
- United States
- Language:
- English
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560151* -- Radiation Effects on Animals-- Man
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYLATING AGENTS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD CHEMISTRY
BODY
BONE MARROW
DELAYED RADIATION EFFECTS
DISEASES
DRUGS
ENDOXAN
EXTERNAL IRRADIATION
FEMALE GENITALS
FEMALES
FERTILITY
FSH
GAMETOGENESIS
GONADOTROPINS
GONADS
HEMATOPOIETIC SYSTEM
HEMIC DISEASES
HORMONES
IMMUNOSUPPRESSIVE DRUGS
IRRADIATION
LEUKEMIA
LH
MALE GENITALS
MALES
NEOPLASMS
ORGANS
OVARIES
PATIENTS
PEPTIDE HORMONES
PITUITARY HORMONES
PREGNANCY
RADIATION EFFECTS
SPERMATOGENESIS
TESTES
TISSUES
TRANSPLANTS
WHOLE-BODY IRRADIATION