Site of iodination in rat mammary gland
Journal Article
·
· Anat. Rec.; (United States)
The ability of the mammary gland to take up and organically bind radioiodide was studied in non-pregnant, pregnant, and lactating rats. Autoradiography was used to determine whether duct cells or alveolar cells are responsible for iodination in the rat mammary gland. Iodination was not detected in mammary glands from non-pregnant rats, but occurred late in the twelfth day of gestation and continued throughout pregnancy and lactation. Protein-containing vacuoles in alveolar cells and casein-like proteins in milk were the major sites where iodination occurred within the gland. Milk proteins in the lumens of ductules adjacent to alveoli were also iodinated. In contrast, ducts, myoepithelial cells, fat cells, blood vessels and other histological components of the gland did not show iodinating capability. Cytochemistry was also used to identify endogenous mammary peroxidase activity in the same glands, and it was found that the presence and location of this enzyme were correlated with the ability to iodinate.
- Research Organization:
- Univ. of Maryland, Baltimore
- OSTI ID:
- 5501840
- Journal Information:
- Anat. Rec.; (United States), Journal Name: Anat. Rec.; (United States) Vol. 192:2; ISSN ANREA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
BODY
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
ELEMENTS
ENZYMES
GLANDS
HALOGENATION
HALOGENS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IODINATION
IODINE
IODINE ISOTOPES
ISOTOPES
LACTATION
MAMMALS
MAMMARY GLANDS
METABOLISM
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
PORPHYRINS
PREGNANCY
PROTEINS
RADIONUCLIDE KINETICS
RATS
RODENTS
UPTAKE
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AUTORADIOGRAPHY
BODY
CARBOXYLIC ACIDS
CHEMICAL REACTIONS
ELEMENTS
ENZYMES
GLANDS
HALOGENATION
HALOGENS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IODINATION
IODINE
IODINE ISOTOPES
ISOTOPES
LACTATION
MAMMALS
MAMMARY GLANDS
METABOLISM
NONMETALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXIDOREDUCTASES
PEROXIDASES
PORPHYRINS
PREGNANCY
PROTEINS
RADIONUCLIDE KINETICS
RATS
RODENTS
UPTAKE
VERTEBRATES