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Clearance of tissue antigens from irradiated animals' blood under the influence of antitissular antibodies

Journal Article · · Radiobiology (USSR) (Engl. Transl.); (United States)
OSTI ID:5500445
It has been demonstrated that preparations of ..gamma..-globulin containing antitissular antibodies have a therapeutic and preventive effect on experimental acute radiation sickness. There is no direct evidence in the available literature of the fact that globulin preparations can bind tissular antigens. However, it was reported that the circulating time of hepatic antigen was much shorter in rats with autoantibodies in blood than in animals without autoantibodies. Circulation of blood antigens in rats exposed to radiation in doses of 10,000 R was demonstrated by the Hoigne reaction with antiserum to spleen tissue and blood plasma. The objective here was to develop a technique for demonstrating the capacity to induce clearance of circulating tissue antigens from blood by means of homologous globulin preparations containing autoantibodies.
OSTI ID:
5500445
Journal Information:
Radiobiology (USSR) (Engl. Transl.); (United States), Journal Name: Radiobiology (USSR) (Engl. Transl.); (United States) Vol. 18:3; ISSN RADBA
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIBODIES
ANTIGENS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLOOD SERUM
BLOOD-PLASMA CLEARANCE
BODY
CLEARANCE
COBALT 60
COBALT ISOTOPES
DATA
DATA FORMS
EARLY RADIATION EFFECTS
ELECTROMAGNETIC RADIATION
EVALUATED DATA
GAMMA RADIATION
GLOBULINS
GRAPHS
IMMUNE REACTIONS
INFORMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
NUMERICAL DATA
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RATS
RODENTS
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES