Effect of copper administration on the incorporation of (3H)-thymidine into the liver DNA of rats stimulated by dimethylnitrosamine and diethylnitrosamine

Journal Article · Wed Dec 31 23:00:00 EST 1980 · Carcinogenesis (N.Y.); (United States)

DOI:https://doi.org/10.1093/carcin/2.12.1261· OSTI ID:5499797

Sakai, K; Murata, N; Chiba, K; Yamane, Y

The incorporation of (3H)thymidine into liver DNA of rats increased 6--8 times 48 h after a single injection of dimethylnitrosamine (DMN, 30 mg/kg) and diethylnitrosamine (DEN, 100 mg/kg). To test the suppressive effect of copper, the incorporation of (3H)thymidine into liver DNA in the DMN groups or DEN groups pretreated with copper was measured 48 h after the administration of DMN or DEN. The incorporation of (3H)thymidine into liver DNA of rats stimulated by the injection of DMN was strikingly suppressed by the injection of cupric acetate (20 mg Cu/kg), but that of rats stimulated by the injection of DEN was not suppressed by the injection of copper. Some other metal salts, silver nitrate (20 mg Ag/kg), nickel acetate (20 mg Ni/kg) and basic lead acetate (20 mg Pb/kg) did not significantly suppress the incorporation of (3H)thymidine stimulated by DMN or DEN. The accumulation of copper was much higher in the liver of copper-administered rats than that of nickel or lead in the liver of nickel-administered rats or lead-administered rats. The accumulation of silver was comparatively high in the liver of silver-administered rats.

• Research Organization: Faculty of Pharmaceutical Sciences, Chiba University, Japan
• OSTI ID: 5499797
• Journal Information: Carcinogenesis (N.Y.); (United States), Journal Name: Carcinogenesis (N.Y.); (United States) Vol. 2:12; ISSN CRNGD
• Country of Publication: United States
• Language: English

Related Subjects

560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACETATES
AMINES
ANIMALS
BIOLOGICAL ACCUMULATION
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACID SALTS
COPPER COMPOUNDS
DIGESTIVE SYSTEM
DNA
DNA REPLICATION
GLANDS
INHIBITION
LABELLED COMPOUNDS
LIVER
MAMMALS
NICKEL COMPOUNDS
NITRATES
NITROGEN COMPOUNDS
NITROSAMINES
NITROSO COMPOUNDS
NUCLEIC ACID REPLICATION
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RATS
RODENTS
SILVER COMPOUNDS
SILVER NITRATES
TRANSITION ELEMENT COMPOUNDS
TRITIUM COMPOUNDS
VERTEBRATES