Comparison of the activity and distribution of analog II and related compounds in the mouse and rat
Conference
·
· Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States)
OSTI ID:5498410
The authors have reported that 1,1-dichloro-Cis-2,3-diphenylcyclopropane (Analog II) is antiestrogenic in the mouse and inhibits the initiation and promotion of DMBA-induced tumors in the rat. Recently the authors have synthesized related cyclopropyl derivative of stilbene and stilbenediol. The object of the present study was to compare the activity of these compounds in the mouse and rat. Estrogenic and antiestrogenic activity of each compound was determined using the 3-day uterotropic assay and uterine histology in immature female Swiss Webster mice and Sprague-Dawley rats. (/sup 3/H)-Analog II was used in the tissue distribution studies. It was found that whereas Analog II was antiestrogenic in the mouse, this compound and related cis-stilbene analogs produced no antiestrogenic activity in the rat. However, trans-stilbenediol derivatives were estrogenic in both the mouse and rat with relatively equivalent activity in both species. In the tissue distribution study (/sup 3/H)-Analog II was found to be specifically concentrated in uterine tissue of the mouse but not the rat. This observation may explain, in part, the difference in antiestrogenic activity of Analog II between these two rodent species.
- Research Organization:
- Univ. of Oklahoma, Oklahoma City
- OSTI ID:
- 5498410
- Report Number(s):
- CONF-8604222-
- Conference Information:
- Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Journal Volume: 45:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
550201 -- Biochemistry-- Tracer Techniques
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
COMPARATIVE EVALUATIONS
DISTRIBUTION
DRUGS
ESTROGENS
FEMALE GENITALS
HORMONE ANTAGONISTS
HORMONES
HYDROCARBONS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
RATS
REACTION KINETICS
RODENTS
STEROID HORMONES
STILBENE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UTERUS
VERTEBRATES
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AROMATICS
BIOCHEMICAL REACTION KINETICS
BIOLOGICAL EFFECTS
BODY
COMPARATIVE EVALUATIONS
DISTRIBUTION
DRUGS
ESTROGENS
FEMALE GENITALS
HORMONE ANTAGONISTS
HORMONES
HYDROCARBONS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MICE
ORGANIC COMPOUNDS
ORGANS
RATS
REACTION KINETICS
RODENTS
STEROID HORMONES
STILBENE
TISSUE DISTRIBUTION
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UTERUS
VERTEBRATES