Cadmium accumulation and protein binding patterns in tissues of the rainbow trout, Salmo gairdneri

Journal Article · Sat Mar 01 04:00:00 EST 1986 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.1289/ehp.8665133· OSTI ID:5497972

Kay, J; Thomas, D G; Brown, M W; Cryer, A; Shurben, D; Solbe, J F.deL.G.; Garvey, J S

Rainbow trout were exposed to defined levels of cadmium in their aquarium water for differing periods at a variety of near-lethal concentrations that ensured the survival of the majority of the fish. The gills, liver and kidney together accounted for 99% of the accumulated load of body cadmium in the fish under these conditions. Although the proportion of total cadmium present in the liver remained relatively constant throughout, the distribution of the remainder between gill and kidney altered with the time of exposure. The cadmium in all three organs was bound by two low molecular weight proteins distinct in character from metallothionein. By contrast, when trout were injected with cadmium intraperitoneally, most of the metal accumulated in the liver where it was sequestered by the two isoforms of metallothionein. Pre-exposure of the trout to either a low concentration of cadmium (for several months) or to an elevated concentration of zinc (for 5 days) allowed the animals to survive a subsequent exposure to a high, otherwise lethal concentration of cadmium.

• Research Organization: Univ. College, Cardiff, Wales
• OSTI ID: 5497972
• Journal Information: Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 65; ISSN EVHPA
• Country of Publication: United States
• Language: English

Related Subjects

550200 -- Biochemistry
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
AQUATIC ORGANISMS
BIOCHEMISTRY
BODY
CADMIUM COMPOUNDS
CHEMISTRY
DIGESTIVE SYSTEM
DISTRIBUTION
ELEMENTS
FISHES
GILLS
GLANDS
KIDNEYS
LIVER
METALLOPROTEINS
METALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RESPIRATORY SYSTEM
TISSUE DISTRIBUTION
TROUT
UPTAKE
VERTEBRATES
ZINC