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Aspects of the testicular toxicity of phthalate esters

Journal Article · · Environ. Health Perspect.; (United States)
DOI:https://doi.org/10.1289/ehp.8665229· OSTI ID:5497930
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Di(2-ethylhexyl) phthalate (DEHP) produced seminiferous tubular atrophy and reductions in seminal vesicle and prostate weight in 4-week-old, but not in 15 -week-old rats. Di-n-pentyl phthalate (DPP) did produce atrophy in the older rats but this developed more slowly than in young animals. Coadministration of testosterone or gonadotrophins did not protect against phthalate-induced testicular toxicity but did partly reverse the depression of seminal vesicle and prostate weight. Secretion of seminiferous tubule fluid and androgen binding protein by the Sertoli cells was markedly suppressed within 1 hr of a dose of DPP or mono-2-ethylhexyl phthalate (MEHP) in immature rats. This occurred less rapidly in mature rats. (/sup 14/C)mono-n-pentyl phthalate and (/sup 14/C)MEHP penetrated the blood testis barrier only to a very limited extent. These findings and the early morphological changes in the Sertoli cells produced by DPP suggest that phthalate esters may act initially to cause Sertoli cell injury, the subsequent loss of germ cells occurring as a consequence of this.
Research Organization:
British Industrial Biological Research Association, Surrey, England
OSTI ID:
5497930
Journal Information:
Environ. Health Perspect.; (United States), Journal Name: Environ. Health Perspect.; (United States) Vol. 65; ISSN EVHPA
Country of Publication:
United States
Language:
English

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Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANDROGENS
ANDROSTANES
ANIMALS
ATROPHY
BIOLOGICAL EFFECTS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
ESTERS
GLANDS
GONADS
HORMONES
HYDROXY COMPOUNDS
KETONES
LABELLED COMPOUNDS
MALE GENITALS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHTHALATES
PHTHALIC ACID ESTERS
PROSTATE
RATS
RODENTS
STEROID HORMONES
STEROIDS
TESTES
TESTOSTERONE
TOXICITY
TRITIUM COMPOUNDS
VERTEBRATES