Direct and inverted reciprocal chromosome insertions between chromosomes 7 and 14 in a woman with recurrent miscarriages

Journal Article · Thu Sep 01 00:00:00 EDT 1994 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320520319· OSTI ID:54879

Wang, Ying-Tai; Wang, Zhao-Cai ^[1]; Bajalica, S; Han, F Y; Bui, T H; Xie, Y G ^[2]

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1. Institute of Medical Genetics, Henan (China)
2. Karolinska Hospital, Stockholm (Sweden)

We present the first case of direct and inverted reciprocal chromosome insertions between human chromosomes 7 and 14, ascertained because of repeated spontaneous abortions. Prometaphase GTG banding analysis showed the karyotype to be 46, XX, inv ins (7;14)(7pter {yields} 7q11.23::14q32.2 {yields} 14q22::7q21.2 {yields} 7qter), dir ins(14;7)(14pter {yields} 14q22::7q11.23 {yields} 7q21.2::14q32.2 {yields} 14qter). Origins of the insertion have been confirmed by chromosome painting with libraries specific for chromosomes 7 and 14 using fluorescence in situ hybridization. 5 refs., 3 figs.

• Sponsoring Organization: USDOE
• OSTI ID: 54879
• Journal Information: American Journal of Medical Genetics, Vol. 52, Issue 3; Other Information: PBD: 1 Sep 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
HUMAN CHROMOSOMES
CHROMOSOMAL ABERRATIONS
GENETIC MAPPING
WOMEN
REPRODUCTIVE DISORDERS
HUMAN CHROMOSOME 14
HUMAN CHROMOSOME 7
ABORTION
HYBRIDIZATION
FLUORESCENCE
KARYOTYPE
BANDING TECHNIQUES
MITOSIS