Influence of. gamma. irradiation on the development of neoplastic disease in mice. II. Solid tumors
Journal Article
·
· Radiat. Res.; (United States)
The influence of /sup 137/Cs ..gamma.. irradiation on the development of solid tumors was investigated using male and female RFM/Un mice. In females the tumor types for which data were sufficient to allow analysis of the form of the dose-response relationship were ovarian, pituitary, and Harderian gland tumors. In males analysis of the dose response was only possible for Harderian gland tumors. The data suggest that a threshold estimated to be 11 to 12 rad may exist for the induction of ovarian tumors. Above this threshold the incidence increased with the square of the dose. A linear-dose-squared model described the dose-response relationship for pituitary tumors in females and Harderian gland tumors in both males and females. The incidences of other tumors were individually too low to allow analysis. The need for understanding the biological basis for the form of the dose response is discussed.
- Research Organization:
- Oak Ridge National Lab., TN
- DOE Contract Number:
- W-7405-ENG-26
- OSTI ID:
- 5487110
- Journal Information:
- Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 80:2; ISSN RAREA
- Country of Publication:
- United States
- Language:
- English
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· Radiat. Res.; (United States)
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Related Subjects
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CESIUM 137
CESIUM ISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
FEMALE GENITALS
FEMALES
GAMMA RADIATION
GLANDS
GONADS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MALES
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
PATHOGENESIS
PITUITARY GLAND
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SEX DEPENDENCE
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
Cells
& Tissue Culture
560121 -- Radiation Effects on Cells-- External Source-- (-1987)
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CARCINOGENESIS
CESIUM 137
CESIUM ISOTOPES
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
ENDOCRINE GLANDS
FEMALE GENITALS
FEMALES
GAMMA RADIATION
GLANDS
GONADS
IONIZING RADIATIONS
IRRADIATION
ISOTOPES
MALES
MAMMALS
MICE
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OVARIES
PATHOGENESIS
PITUITARY GLAND
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RODENTS
SEX DEPENDENCE
TUMOR CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES